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Publications and Communications of Research Group of Yves A. Lussier Funded in part by the National Library of Medicine Medical Informatics Training Grant 1K22 LM008308




 

Refereed Journal Publications

1           Tao Y, Friedman C[1], Lussier YA*. The Use of Information Visualization Techniques in Bioinformatics during the Postgenomic Era. Biosilico 2004; Vol. 2, No. 6. [Cited by 21]http://dx.doi.org/doi:10.1016/S1741-8364(04)02423-0


2           Tao Y, Friedman C*, Lussier YA*. "Visualizing information across multidimensional post-genomic structured and textual databases" Bioinformatics. 2005 Apr 15;21(8):1659-67. Epub 2004 Dec 14. [Cited by 11]   http://dx.doi.org/doi:10.1093/bioinformatics/bti210


3           Choi J, Bakken S*, Lussier YA*, Mendonca EA*. Improving the Human Readability of Arden Syntax Medical Logic Modules Using a Concept-oriented Terminology and Object-oriented Programming Expressions. Comput Inform Nurs. 2006 Jul-Aug; 24(4):220-5.http://www.cinjournal.com/pt/re/cin/abstract.00024665-200607000-00009.htm;jsessionid=LJffpp7n2MQJTs1vzPTSVLRN1h4Tv1CS254lSY8nQ3MTpnKg7k5n!612563345!181195628!8091!-1


4           Tulipano KP, Tao Y, Zanzonico P, Kolbert K, Millar WS, Xu H, Yu H, Chen L, Lussier YA*, Friedman C*. Natural Language Processing and Visualization in the Molecular Imaging Domain. Journal of Biomedical Informatics, 40 2007; 270-281.http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHD-4M0575V-1&_user=5745&_coverDate=06/30/2007&_rdoc=1&_fmt=high&_orig=search&_sort=d&_docanchor=&view=c&_searchStrId=1274979774&_rerunOrigin=google&_acct=C000001358&_version=1&_urlVersion=0&_userid=5745&md5=262fa03446369717da769e673014a7ad


5           Friedman C*, Borlawsky T, Xing HR, Lussier YA*. Bio-Ontology and Text: Bridging the Modeling Gap. Bioinformatics, 2006 Oct 1;22(19):2421-9. http://dx.doi.org/doi:10.1093/bioinformatics/btl405


6           Liu Y, Li J, Sam L, Goh CS, Gerstein M*, Lussier YA*. From phenotypes to genotypes: A meta-genomic approach to uncover the molecular mechanisms of prokaryotic traits. PLoS Computational Biology, 2006 2(11): 1419-1435. [Cited by 26]http://dx.doi.org/doi:10.1371/journal.pcbi.0020159
·         Editor's Pick of the month
·         Selected as Highlights of 2007 (30 mansucripts selected in ) for presentation in the International Symposium on Molecular Biology (ISMB 2007).


7           Chen JL, Sam L, Tao Y, Liu Y, Lussier YA*. High-throughput functional classification of human disease genes. Semantic e-Science Workshop 2006 supplements. BMC Bioinformatics 2007, 8(Suppl 3):S7http://dx.doi.org/doi:10.1186/1471-2105-8-S3-S7


8           Lussier YA*, Liu Y. Computational Approaches to Phenotyping: High-Throughput Phenomics. Proc Am Thorac Soc Vol 4. pp 18-25, 2007. [Cited by 20]http://dx.doi.org/DOI:10.1513/pats.200607-142JG


9           Tao Y, Li J, Friedman C*, Lussier YA*. Information Theory Applied to the Sparse Gene Ontology Annotation Network to Predict Novel Gene Function. Bioinformatics, 2007, 23(13)i5[2]29-38. (400 papers, 15% acceptation). [Cited by 33]http://dx.doi.org/doi:10.1093/bioinformatics/btm195


10       Bales M, Lussier YA*, Johnson SB*. Topological analysis of large-scale biomedical terminology structure.  J Am Med Inform Assoc. epub 2007 Aug 2, 2007 Nov每Dec; 14(6): 788每797.http://dx.doi.org/DOI:10.1197/jamia.M2080
http://www.pubmedcentral.nih.gov/picrender.fcgi?tool=pmcentrez&artid=2213477&blobtype=pdf


11       Liu Y, Sam L, Li J, Lussier YA*. Robust Methods for Accurate Diagnosis Using Pan-Microbiological Oligonucleotide Microarrays. BMC Bioinformatics,. 2009 Feb 5;10 Suppl 2:S11.http://www.biomedcentral.com/1471-2105/10/S2/S11
·         Outstanding Paper Award from the American Medical Informatics Association.


12       Sam L. Li J, Mendonca E, Friedman C, Lussier YA*. PhenoGO: A Resource for Mining Multiscale Biological and Clinical Data. BMC Bioinformatics.. 2009 Feb 5;10 Suppl 2:S8. [Cited by 9]  http://www.biomedcentral.com/1471-2105/10/S2/S8
·         Outstanding Paper Award from the American Medical Informatics Association.


13       Pantazatos SP, Li J, Pavlidis P, Lussier YA*. Integration of Neuroimaging and Microarray Datasets through Mapping and Model-Theoretic Semantic Decomposition of Unstructured Phenotypes. Cancer Informatics, 2009:8 75每94. http://la-press.com/article.php?article_id=1484
·          Highly visible  (1153 readers in 6 months).


14       Yang X, Huang Y, Chen J, Xie J, Sun X, Lussier YA*. Mechanism-Anchored Profiling derived from Epigenetic Networks Predicts Outcome in Acute Lymphoblastic Leukemia. BMC Bioinformatics 2009, 10(Suppl 9):S6 (17 September 2009).http://www.biomedcentral.com/1471-2105/10/S9/S6
·          Outstanding Paper Award from the American Medical Informatics Association.


15       Yang X, Lee Y,  Fan H, Sun X*, Lussier YA*. Identification of common microRNA-mRNA regulatory biomodules in human epithelial cancers. Chinese Science Bulletin, in press http://www.springerlink.com/content/1001-6538/
http://phenos.bsd.uchicago.edu/publication/biomodule/microRNA_revised_resubmit_June262009.pdf


16       Yang X§, Lee Y§, Huang Y, Chen J, Xing HR* , Lussier YA*.Stromal Microenvironment Processes Unveiled by Biological Component Analysis of Gene Expression in Xenograft Tumor Models. In press, BMC Bioinformatics.
·         "Selected for publication in BMC Bioinformatics as part of a special relationship between AMIA and BMC to recognize twelve exceptional 2010 TBI Summit papers."


17       Lee Y§, Yang X§, Huang Y§, Fan H§, Zhang Q, Wu Y, Li J, Hasina R, Cheng C, Lingen M, Gerstein M, Weichselbaum R, Xing HR*,  Lussier YA*. MiR-204 suppresses tumor invasion by regulating molecular networks of cell adhesion and extracellular matrix remodelling. In press, PLoS Computational Biology.In press, PLOS Computational Biology.
·          One of the 24 best translational bioinformatics reports of 2009-10, by Russ Altman, in his review presented at the  2010 American Medical Informatics Association Summit on Translational Bioinformatics and on his blog http://rbaltman.wordpress.com/ (page 36 of the PDF file, URL below):
http://go2.wordpress.com/?id=725X1342&site=rbaltman.wordpress.com&url=http%3A%2F%2Ffiles.me.com%2Frussbaltman%2F71b0xt
·          Selected as late breaking news (5 selected) for highlight in The 2010 American Medical Informatics Association Summit on Translational Bioinformatics; S12, p.17 (program below). http://summit2010.amia.org/files/symposium2008/AMIA_TBI_On-Site_Program.pdf


18       Chen J§, Sam L§, Huang Y§, Lee Y, Li J, Liu Y, Xing HR, Lussier YA*. Protein Interaction Network Underpins Concordant Prognosis Among Heterogeneous Breast Cancer Signatures. in press, Journal of Biomedical Informatics.

 

 Refereed Conference Papers

19       Cantor MN, Lussier YA*. Putting Data Integration into Practice: Using Biomedical Terminologies to Add Structure to Existing  Data Sources. AMIA Annu Symp Proc.2003:125-9. [Cited by 24]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1480054/pdf/amia2003_0125.pdf


20       Lussier YA*, Li J. Terminological Mapping For High Throughput Comparative Biology of Phenotypes. Pac Symp Biocomput. 2004;:202-13. [Cited by 22]http://helix-web.stanford.edu/psb04/lussier.pdf


21       Tao Y, Mendonca EA, Lussier YA*. "A tool for Abstracting Relevant Classes of Concepts: the Common Ancestry Summarizer". Medinfo. 2004;11(Pt 1):449-53.http://cmbi.bjmu.edu.cn/news/report/2004/medinfo2004/pdffiles/papers/5513Tao.pdf


22       Cantor MN, Lussier YA*. "Mining OMIM for Insight in Complex Diseases". Medinfo. 2004;11(Pt 2):753-7. [Cited by 16]http://cmbi.bjmu.edu.cn/news/report/2004/medinfo2004/pdffiles/papers/4054Cantor.pdf


23       Cantor MN, Sarkar IN, Bodenreider O, Lussier YA*. Genestrace: Phenomic Knowledge Discovery Via Structured Terminology. Pac Symp Biocomput. 2005;:103-14. [Cited by 15]http://helix-web.stanford.edu/psb05/cantor.pdf


24       Lussier YA*, Borlawsky T, Rappaport D, Friedman C*. PhenoGO: a Multistrategy Language Processing System Assigning Phenotypic Context to Gene Ontology Annotations. Pac Symp Biocomput., 2006;:64-75. [Cited by 35]http://psb.stanford.edu/psb-online/proceedings/psb06/abstracts/2006_p64.html


25       Borlawsky T, Friedman C, Lussier YA*. Generating Executable Knowledge for Evidence-Based Medicine Using Natural Language and Semantic Processing. AMIA Annu Symp Proc. 2006, pp.56-60. [Cited by 3] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1839756/pdf/AMIA2006_0056.pdf


26       Pantazatos SP; Li J; Pavlidis P; van Horn JD, Lussier YA*. Cross-Scale Mapping of Gene Expression to Neuroimaging Datasets via Semantic Decomposition. Medinfo 2007: Proceedings of the 12th World Congress on Health (Medical) Informatics; Building Sustainable Health Systems; pages: [2282]-[2284]. Kuhn, Klaus A (Editor); Warren, James R (Editor); Leong, Tze-Yun (Editor). Amsterdam: IOS Press, 2007. Studies in health technology and informatics, ISSN 0926-9630 ; v. 129. Availability: <http://search.informit.com.au/documentSummary;dn=793670817490533;res=IELHSS> ISBN: 9781586037741[Cited by 1]http://phenos.bsd.uchicago.edu/public/medinfo2007.pdf


27       Sam L, Li J, Liu Y, Friedman C*, Lussier YA*. Discovery of Protein Interaction Networks Shared by Diseases. Mining Gene Ontology and Medline for Protein Networks in Complex Diseases. Pac Symp Biocomput, 12:76-87(2007). [Cited by 11]http://psb.stanford.edu/psb-online/proceedings/psb07/sam.pdf


28       Chen ES, Stetson PD, Lussier YA, Markatou M, Hripcsak G, Friedman C. Detection of Practice Pattern Trends through Natural Language Processing of Clinical Narratives and Biomedical Literature. AMIA Annu Symp Proc. 2007 Oct 11:120-4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655911/pdf/amia-0120-s2007.pdf


29       Tao Y, Patel C,  Friedman C, Lussier YA*. PIE: A Phenotype Interface Engine for Automated Representation in PATO and "Semantic Web"-Based Exchange of Clinical Data and Narratives. AMIA Annu Symp Proc. AMIA Annu Symp Proc. 2007 Oct 11:p.645-http://www.amia.org/meetings/f07/showDoc.asp?DID=545


30       Lee Y, Li J, Gamazon E, Tikhomirov A, Cox NJ*, Lussier YA*. Biomolecular Systems of Disease Buried Across Multiple GWAS Unveiled by Information Theory and Ontology.  Proceedings of the 2010 AMIA Summit on Translational Bioinformatics.


31       Borlawsky-Payne T, Li J, Friedman C*, Lussier YA*,. BiomedLEE: High Throughput Encoding of Genes and Phenotypes from Biomedical Narratives Based on Natural Language Processing. Proceedings of the 2010 AMIA Summit on Translational Bioinformatics.


32       Yang X§, Lee Y§, Huang Y, Chen J, Xing HR* , Lussier YA*.Stromal Microenvironment Processes Unveiled by Biological Component Analysis of Gene Expression in Xenograft Tumor Models. Proceedings of the 2010 AMIA Summit on Translational Bioinformatics,
·         accepted for publication in BMC Bioinformatics among top 12 mansucripts of the conference.

 

Reviews, Chapters, Session Introductions and Editorials


33       Côté RA; Lussier YA: "Glossary of signs and symptoms". American College of Pathology, Secretariat of the Systematized Nomenclature of Veterinary and Human Medicine. SNOMED vers 3.2, (CD), 1995. http://www.jamia.org/cgi/content/citation/2/1/68


34       Lussier YA§[3], Jenders R§, Mendonça EA§: "Clinical Decision Support Systems." Healthcare Information Systems, 2nd Ed. Best Practices Series, Auerbach, Beaver K ed. Chapter 17, 2003:221-36.http://books.google.com/books?id=nGxHhFmvwcEC&pg=PA221&lpg=PA221&dq=%22Clinical+Decision+Support+Systems%22+jenders+lussier&source=web&ots=5g3hFlb8JD&sig=A5nKDFWPK9ZY858jWY_0wFkgPUI&hl=en&sa=X&oi=book_result&resnum=1&ct=result
Kukafka R, Lussier YA, Cimino JJ. Chapter# 19 "The MI-HEART Project" p.227-238 in  "Social Informatics and Consumer Health: Opportunities and Issues" in Lewis, D., Eysenbach, G., Kukafka, R., Stavri, Z., and Jimison, H. Consumer Health Informatics. Springer-Verlag, New York. 246p. pp.227-238 (2005). http://www.springerlink.com/content/hl64488467x32612/fulltext.pdf
http://books.google.com/books?id=y6S_K7U_3w8C&pg=PR18&lpg=PR18&dq=%22The+MI-HEART+Project%22+kukafka+cimino+jimison&source=web&ots=MOhTSx7tr4&sig=vH3o8gQyunoKrLaz19Srs44yWyw&hl=en&sa=X&oi=book_result&resnum=3&ct=result


35       Lussier YA*: Chapter 99 on "Ontologies and Natural Language Processing". Russ Altman, Shankar Subramaniam. Volume 4: Bioinformatics. Encyclopaedia of Genetics, Genomics, Proteomics and Bioinformatics, John Wiley & Sons, (2005 pp. 1-17 specialist review).http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470849746,descCd-tableOfContents.html


36       Stevens R*, Bodenreider O*, Lussier YA*. Semantic webs for life sciences. Pac Symp Biocomput. 2006;:112-5.  http://helix-web.stanford.edu/psb06/intro-sem.pdf


37       Lussier YA*, Shortliffe EH: Chapter 22 (Final Chapter): IT-Related Grand Challenges in Medicine and Health".pp.441-452 Harold P Lehmann, Patricia A Abbott, Nancy R Roderer, Adam Rothchild, Steven Mandell, Jorge A Ferrer, Robert E Miller, Marion J Ball, Editors, "Aspects of the Computer Patient Record", 2nd Ed. Springer-Verlag, 2006 483p.http://books.google.com/books?id=TIMbyCFpeUwC&pg=PT463&lpg=PT463&dq=IT-Related+Grand+Challenges+in+Medicine+and+Health+shortliffe&source=web&ots=FCTfx0NOw8&sig=-wrijD5Qum4Txuj9OsQfbEBzJxQ&hl=en&sa=X&oi=book_result&resnum=2&ct=result


38       Lussier YA*, Bodenreider O*. Clinical Ontologies for Discovery Applications. pp.101-119 Chritopher Baker and Kei Cheung, Editors. Semantic Web: Revolutionizing Knowledge Discovery in the Life Sciences. Springer Verlag 2007, XXII, 450 p.http://www.springerlink.com/content/t188446mn90r75r7/


39       Lussier YA*, Younghee Lee Y, Radivojac P, Ofran Y, Punta M, Butte A, Kann M; Session Introduction. Molecular Bioinformatics for Diseases: Protein Interactions and Phenomics. Pacific Symposium on Biocomputing 13:228-230(2008)http://psb.stanford.edu/psb-online/proceedings/psb08/bioinfo.pdf


40       Lussier YA*, Crowson M, chapter on "Natural language Processing for Database Systems", The Encyclopaedia of Database Systems, Springer 2009. Özsu, M. Tamer; Liu, Ling (Eds.) 2009,(in press) Approx. 4000 p. ISBN: 978-0-387-49616-0.http://www.springerlink.com/content/r87v0v7n921656q0/fulltext.html


41       Lussier YA*, Chen J, chapter on "Clinical Ontologies", The Encyclopaedia of Database Systems, Springer 2009 Özsu, M. Tamer; Liu, Ling (Eds.) 2009, (in press) Approx. 4000 p. ISBN: 978-0-387-49616-0. http://www.springerlink.com/content/v903264116q61u81/fulltext.html


42       Lussier YA, Lee Y, Radivojac P, Ofran Y, Butte A, and Kann M.  Molecular Bioinformatics for Disease  - Session Introduction. Pacific Symposium on Biocomputing 14:464-466(2009)http://psb.stanford.edu/psb-online/proceedings/psb09/intro-bioinfo.pdf


43       Mendonça E*, Lussier YA*, chapter "The frontiers of cancer phenomics", book "An 'Omics' perspective of Cancer" , Chapter 11, pp.204-10 Springer, 2009. http://www.springer.com/biomed/book/978-90-481-2674-3


44       Butte AJ, Sarkar IN, Ramoni M, Lussier Y, Troyanskaya O. Selected proceedings of the First Summit on Translational Bioinformatics 2008. BMC Bioinformatics. 2009 Feb 5;10 Suppl 2:I1. doi:10.1186/1471-2105-10-S2-I1 http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2646246&blobtype=pdf


45       Lussier Y, Butte A, Hunter L. Special Issue on Methodologies for Translational Bioinformatics. Journal of Biomedical Informatics, 42 (2009) 201-2.http://www.elsevier.com/framework_products/promis_misc/Lussier_CFP.pdf


46       Lussier Y, Sarkar IN. Selected proceedings of the 2009 Summit on Translational Bioinformatics. BMC Bioinformatics 2009, 10(Suppl 9):I1 (17 September 2009).http://www.biomedcentral.com/1471-2105/10/S9/I1


47        Lee Y, * Huang Y, Fan H, Wu Y, Li J, Zhang Q, Hasina R, Arakaki A, Skolnickj J, Lingen M, Weichselbaum R, Xing HR*,  Lussier YA*. Computational Prediction and Thorough Biological Characterization Uncovers a Tumor Suppressor microRNA and its Regulatory Network. 2010 American Medical Informatics Association Summit on Translational Bioinformatics.
·         Highlighted as late breaking news (one of five selected news)

 

 

Published Refereed Abstracts and Refereed Conference Panels

48       Tao Y, Mendonca EM, Lussier YA*. A "Systematics" Tool for Medical Terminologies. AMIA Annu Symp Proc 2003;:1028. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1480204/pdf/amia2003_1028.pdf

49       Lussier YA*. Automated Terminological Networks For High Throughput Comparative Biology of Phenotypes. Interface 2004, Computational Biology and Bioinformatics, 36th Symposium on the Interface, Baltimore Marriott Waterfront Hotel, Baltimore, Maryland, May 26-29, 2004.

50       Sarkar IN, Cantor MN, Bodenreider O, Lussier YA*. GenesTrace (TM): Biological Knowledge Discovery via Structured Terminology. MEDINFO 2004, p.1842.San Francisco.

51       Lussier YA*. Overview of Clinical Genomics Technology. SS114 Bringing Context and Consistency to the Genomic Revolution - Creating Visible Man. Annual Meeting of the College of American Pathologist. Sept. 19-22, 2004, Phoenix.

52       Patel C, Lussier YA*. Re-representing Biomedical Ontologies using the Web Ontology Language - A Checklist. Standards and Ontologies for Functional Genomics 2. Oct 23, 2004 - Oct 26, 2004, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

53       Lussier YA*. Computational Ontologies for High Throughput Visualization and Analyzes of the Phenome. Standards and Ontologies For Functional Genomics 2, Oct 23-26, 2004, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

54       Lussier YA*. "Impact of Healthcare Practices and Financing on Clinical Informatics Applications and Research: A Proposed Predictive Model". International Colloquium. Reflections and Realities: How Much Impact Has Our Health/Medical Informatics Research Had On Our Health Care Systems? University of Victoria, June 3-4, 2005.

55       Lussier YA*, Liu Y, Skolnick J, Gerstein M. Progress of the Biomedical Informatics Core. Annual Meeting of the Northeast Research Center of Excellence in Biodefense and Emerging Infectious Diseases. Cold Spring Harbor Laboratories, 2005/9.

56       Tulipano K, Tao Y, Zanzonico P, Kolbert K, Lussier YA, Friedman C. Natural Language Processing in the Molecular Imaging Domain. AMIA Annu Symp Proc 2005;:1143.http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16779429

57       Lussier YA*, Bodenreider O*, Kashyap V, Patrick TB, Neumann E, Rector A. Panel: Towards a Semantic Web For Life Sciences? AMIA Annu Symp Proc 2005.

58       Borlawsky T,  Li J, Jalan S, Stern E, Williams R, Lussier YA*. Partitioning Knowledge Bases between Advanced Notification and Clinical Decision Support Systems. AMIA Annu Symp Proc  2005;:901.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1560494/pdf/amia2005_0901.pdf

59       Lussier YA*, Li J, Liu Y, Patel C, Hsiao T, Quek HN Computational approaches for genome scale analyses of phenotypes〞Bridging the phenotypic gap between clinical repositories and model organism databases. Genome Informatics 2005. p.89.Fri 10/28 - Tue 11/01 2005. Cold Spring Harbor Laboratory.

60       Sam L, Borlawsky T, Rappaport D, Li J, Shagina L, Liu Y, Friedman C, Lussier YA*. Towards a Eukaryotic Phenome: the PhenoGO Database System. Pac Symp Biocomput 2006.

61       Tao Y, Patel C, Friedman C*, Lussier YA*. OWL-based Interoperation of  Clinical and Genetic Phenotypes anchored with the Phenotypes Attribute Ontology of the GO Consortium. "Biomedical Ontology in Action/KR-MED 2006 International Workshop" organized by the National Center for Ontology Research (NCOR), and the American medical Informatics Association (Biomedical Knowledge Working Group 每Baltimore Nov 8, 2006.

Bales ME, Lussier YA*, Johnson SB*. Topological analysis of large-scale biomedical terminology structure. AMIA Annu Symp Proc 2006.

62       Tao Y, Li J, Friedman C, Lussier YA*. Predicting New Functions of Human Genes from the Network of Gene Ontology Annotations. Pac Symp Biocomput 2007.

63       Liu Y, Li J, Sam L, Goh CS, Gerstein M*, Lussier YA*. Computational Proteomics: High-throughput Analysis for Systems Biology. Pac Symp Biocomput 2007.

64       Chen J, Lussier YA*. Automated functional classification of Human Disease Genes. Pac Symp Biocomput 2007.

65       Lussier YA*, Friedman C*. BiomedLEE: a natural-language processor for  extracting and representing phenotypes, underlying molecular mechanisms and their relationships. ISMB 2007 (Intelligent Systems for Molecular Biology).http://www.iscb.org/uploaded/css/O02Lussier.pdf

66       Liu Y, Li J, Sam L, Goh CS, Gerstein M, Lussier YA*. An integrative genomic approach to uncover molecular mechanisms of prokaryotic traits'. ISMB 2007 . http://www.iscb.org/uploaded/css/C003Lussier.pdf

67       Liu Y, Li J, Sam L, Lussier YA*. Robust Methods for Accurate Diagnosis Using Highly Multiplexed Microbiological Arrays. ". ISMB 2007 929 submissions, 10% acceptation rate.http://www.iscb.org/uploaded/css/I20Liu.pdf

68       Liu Y, Li J, Sam L, Goh CS, Gerstein M, Lussier YA*. An Integrative Genomic Approach to Uncover Molecular Mechanisms of Prokaryotic Metaphenotypes. 1st Midwest Symposium on Computational Biology and Bioinformatics (MSCBB). http://cbb.northwestern.edu/MSCBB/index.php

69       Chen ES, Lussier YA,  Borlawsky TA, Qureshi K, Hripcsak G*. Monitoring the Function and Use of a Clinical Decision Support System. AMIA Annu Symp Proc. 2007 ; :902.

70       Liu Y, Sam L, Lussier YA*. Robust Informatics Methods for Accurate Diagnosis Using Highly Multiplexed Virus Arrays, AMIA Ann Proc. 2007, Oct 11:1039.

71       Sam L, Borlawsky T, Tao Y,  Li J,  Friedman C, Smith B, Lussier YA. Information-Theoretic Classification of SNOMED Improves the Organization of Context-Sensitive Excerpts from Cochrane Reviews .  AMIA Ann Proceed 2007, P.1100.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655812/pdf/amia-0645-s2007.pdf

72       Yang X, Lussier YA*. Common MicroRNA-mRNA Regulatory Biomodules Predicted in Human Epithelial Cancers. AMIA 2010 Summit in translational Bioinformatics co-sponsored by ISMB. March 2010, San Francisco; Track 1, p.26.http://summit2010.amia.org/files/symposium2008/AMIA_TBI_On-Site_Program.pdf

73       Chen J, Lussier YA*. Mechanism-anchored Prognosis Meta-Signature of Breast Cancer unveiled by Protein Interaction Networks. AMIA 2010 Summit in translational Bioinformatics co-sponsored by ISMB, March 2010, San Francisco; S14, p.18.http://summit2010.amia.org/files/symposium2008/AMIA_TBI_On-Site_Program.pdf

74       W. Zhang, E. Gamazon, R. Huang, University of Chicago; S. Duan, Singapore Institute for Clinical Sciences; W. Bleibel, M. Welsh, Y. Lussier, M. Dolan. MicroRNA Signatures of Cytotoxicity Unveils Molecular Underpinnings of Chemotherapeutic Drug Classes. AMIA 2010 Summit in translational Bioinformatics co-sponsored by ISMB, March 2010, San Francisco; S9,p.16.http://summit2010.amia.org/files/symposium2008/AMIA_TBI_On-Site_Program.pdf

75       Y. Lee, X. Yang, Y. Huang, H Fan, Q. Zhang, Y. Wu, J. Li, R. Hasina, M. Lingen, M. Gerstein, R. Weichselbaum, H. Rosie Xing, Y. Lussier*. Network Modeling Identifies Molecular Functions Targeted by miR-204 to Suppress Head and Neck Tumor Metastasis. AMIA 2010 Summit in translational Bioinformatics co-sponsored by ISMB, March 2010, San Francisco; S12,p.17.http://summit2010.amia.org/files/symposium2008/AMIA_TBI_On-Site_Program.pdf

76       Y. Lee, X. Yang, Y. Huang, H. Fan, Q. Zhang, Y. Wu, J. Li, R. Hasina, C. Cheng, M. Lingen, M. Gerstein, R. Weichselbaum, H. Xing, Y. Lussier*. Computational Phenomics and Thorough Biological Characterization Uncovers a Tumor Suppressor microRNA and its Regulatory Network. AMIA 2010 Summit in translational Bioinformatics co-sponsored by ISMB, March 2010, San Francisco; S16,p.19.http://summit2010.amia.org/files/symposium2008/AMIA_TBI_On-Site_Program.pdf

Extramural Grand Rounds and Invited Clinical Lectures

77       Lussier YA.  "Clinical Genomics." Grand Rounds, NYPH Allen Pavilion. 3/20/2003.

78       Lussier YA.  "Clinical Genomics Updates." Grand Rounds, NYPH Allen Pavilion, New York. 7/15/2004.

79       Lussier YA. SNOMED and the Art of Bioinformatics. SNOMED CT® Implementation Solutions: The Future is Now, 6th Annual SNOMED International Users Group, September 22-24, 2004, Phoenix.

80       Lussier YA.  "Clinical Genomics Technologies, Updates." Grand Rounds,  NYPH Milstein Hospital, New York. Nov 2nd 2004.

81       Lussier YA. Computational Systems Biology and Medicine: Approaches to high throughput and large scale analyses of phenotypes. Conference Series of General Internal Medicine of the Dept of Medicine, Columbia University, 11/05/2005.

82       Lussier YA. "Predicting the Molecular Underpinnings of Complex Phenotypes with High Throughput Phenomics". Grand Rounds of Rheumatology, The University of Chicago, Feb 13 2007. Rich - rkeating@medicine.bsd.uchicago.edu

83        Lussier YA. "Computational Approaches to Unveiling Novel Protein-Protein Interactions in Diseases". Emergency Resuscitation Center, The University of Chicago, Feb 22 2007. Rich - Michael Retzer mretzer@medicine.bsd.uchicago.edu

84       Lussier YA. "High-Throughput Analysis of Novel Protein-Protein Interactions in Diseases". Breast Cancer Seminar Series, The University of Chicago, April 3 2007. Rich - Michael vdeltoro@medicine.bsd.uchicago.edu 4:30 每 W630

85       Lussier YA. Genomic Technologies: clinical challenges and opportunities. Translational Bioinformatics: Desiderata for well designed research databases & Analysis of molecular, genetic, genomic, biological and clinical data. Advanced Topics in Clinical Series, Dept. of Medicine, The University of Chicago, June 7th  2007. Lussier Lecture to housestaff A7-noon

86       Lussier YA. Proteomic Technologies: clinical challenges and opportunities. Translational Bioinformatics: Desiderata for well designed research databases & Analysis of molecular, genetic, genomic, biological and clinical data. Advanced Topics in Clinical Series, Dept. of Medicine, The University of Chicago, June  21th  2007.

Invited Scientific Lectures and Invited Conference Panels

87       Lussier YA. Database Schema for Clinical Genomics. First Genetic Trust, Sept. 2003, New Jersey.

88       Lussier YA.  "Phenotypic Networks and the Art of Bioinformatics" University of Buffalo Center of Excellence in Bioinformatics. 5/6/2004.

89       Friedman C, Lussier YA. Biomedical Informatics Tools for Curators. Jackson Laboratories, Mouse Genome Informatics, June 29, 2004, Bar Harbor.

90       Lussier YA. Phenomic Program of the Lussier Research Group. IBM Watson Laboratories, Hawthorne.. Nov 3rd 2004.

91       Lussier YA. "Hypothesis-Driven Computational Methods for Molecular Medicine and Systems Biology: Genome Scale Integrative Analyses of Phenotypes". School of Health Information Science in The University of Texas Health Science Center at Houston, 6/8/2005.

92       Lussier YA. "Computational approaches for genome scale analyses of phenotypes: bridging the phenotypic gap between clinical repositories and model organism databases". Center for Genetic Medicine and Dept. of Cell and Molecular Biology, Northwestern University Medical School, Chicago, June 13th 2005.

93       Lussier YA. "Research Technical Discussions on Ontologies in Biomedicine", Industry Solution Laboratory,  IBM Watson Research Center, Hawthorne, NY, July 8th, 2005.

94       Lussier YA. "Computational approaches for genome scale analyses of phenotypes: improving the understanding of biological systems and the diagnosis of diseases" Department of Pathology, Division of Biological Sciences, University of Chicago, July 12th  2005.

95       Lussier YA. "Systems Biology approaches to the Metagenomic Analysis of Phenotypes". Department of Biomedical Informatics, Vanderbilt University, Nashville, August 11th 2005.

96       Lussier YA. "Bridging the Phenotype Gap: Ontology-Anchored Computational Methods for Biomedicine". Knowledge-Based Bioinformatics Workshop Hosted by the Genome Qu谷bec funded project: Ontologies, the semantic web and intelligent systems for genomics. September 21st - 23rd 2005; Montr谷al, Qu谷bec, Canada.

97       Lussier YA. Bio-ontologies and Database Integration. Buffalo-Columbia workshop on ontology and cancer bioinformatics. New York State Center of Excellence in Bioinformatics and Life Sciences. Friday, October 14 2005, 280 Park Hall, University at Buffalo.

98       Lussier YA. "Collecting and Integrating Phenotypic Information from Multiple Databases for Correlation with Genomic Databases. Toyota Technological Institute at Chicago, 4/10/2006.

99       Lussier YA. Systems Properties in a Comprehensive Genomic Networks.  Computation Institute, University of Chicago, July 2006.

100   Kann M, Ofran Y, Punta M, Radijovac P, Lussier YA, Panelists. Discussion Session: Protein Interactions in Diseases. Pacific Symposium in Biocomputing, Jan 4th 2007, Maui.

101   Lussier YA. Phenomic Data and its Valuation Chain.  Computational Biology Seminar, Division of Molecular and Computational Biology, Dept. Computational Biology & Bioinformatics, University of Southern California, (invited for March 18th? Xianghong Jasmine Zhou Michael Waterman xjzhou@college.usc.edu).

102   Lussier YA. Emerging Systems Properties in High Throughput Phenomic Studies. Annual CI Fellows meeting, Computation Institute, University of Chicago, February 21, 2007.

103   Lussier YA. Emerging Systems Properties in a Comprehensive Genomic Network of Prokaryotic Traits. Mathematics for Systems Biology Seminar Series: "Emergence in Complex Systems", Computation Institute, University of Chicago, February 22, 2007.

104   Sam L, Li J, Liu Y, Friedman C, Lussier YA*. Predictions of Phenotypic Biomodules in Protein Interaction Networks. Annual meeting of the National Research Center for Multiscale Analyses of Genomic and Cellular Networks (MAGNET), Wavehill, NY, April 6, 2007.

105   Lussier YA. Ontology Similarity Networks and Database Interoperability. Interface 2007, May 23-26, Philadelphia.

106   Lussier Y. Computational Systems Biology approaches to Elucidating Functional Mechanisms Underpinning Molecular Profiles of Cancers. AACR 2007, Nov 27th 每Dec 1st, 2007, Atlanta.

107   Lussier YA. Computational Systems Biology approaches to Elucidating Functional and Molecular Mechanisms of Diseases.  University of Chicago Gastro Enterology Research Conference, December 6th, 2007.

108   Lussier YA. Resources for Multiscale Analysis of Cellular Networks and ECM. National Center for Biomedical Ontology. Cellular Networks Workshop. Newark, NJ, March 28th, 2008.

109   Lussier YA. Protein Interaction and Diseases, a year*s review. The University of Chicago CTSA Biological Translational Research Workshops Presentation. March 31st 2008.

110   Lussier YA. Predictions of Phenotypic Biomodules in Protein Interaction Networks. Annual meeting of the National Research Center for Multiscale Analyses of Genomic and Cellular Networks (MAGNET), Wavehill, NY, April 6, 2007.

111   Lussier YA. Clinical Monitoring: Ontology-Anchored, NLP-Enabled, User-Directed Pharmacovigilence. Conference on Semantics in Healthcare & Life Sciences (C-SHALS, an official conference of the International Society for Computational Biology), March 5-7 2008, Boston.

112   Lussier YA.  Networks, Protein Interactions and Diseases. Center for Computational Biology & Bioinformatics. Indiana University School of Medicine. April 14th, 2008, Indianapolis, IN.

113   Lussier YA.  Systems Biology of microRNAs in Cancer: A case study of Biomolecular Networks and Functional Modules. City of Hope Cancer Center, June 2008

114   Lussier YA.  Decision Making and Individualized Healthcare: Managing Informatics R&D to achieve ROI. Philips Research, NY, Oct 8th 2008

§ These authors have contributed equally to the work.
* Corresponding author(s)